Conference Posters

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FT4 Powder Rheometer Overview Poster

A summary of the FT4 Powder Rheometer's methodologies: Dynamic Flowability, Aeration, Consolidation, Compressibility, Permeability and Shear Cell / Wall Friction

Application of Powder Rheology for Evaluating the Flow Behaviour of Powders for Additive Manufacturing

Jamie Clayton, Tim Freeman, Katrina Brockbank (Freeman Technology) and Robert Deffley (LPW Technology)

This study investigates the flow behaviour of samples of a commonly used titanium alloy sources from different suppliers and produced ...

Comparing the Flow Behaviour of FCC Catalysts using the FT4 Powder Rheometer

Tim Freeman, Jamie Clayton, Katrina Brockbank (Freeman Technology) and Ray Cocco, S.B. Reddy Karri (Particulate Solid Research Inc)

In this study, FCC catalysts with differing fines content, were characterised using the FT4 Powder Rheometer with the aim of ...

Enhancing the Use & Reuse of Metal Powder for Additive Manufacturing

John Yin (Freeman Technology) and Robert Deffley (LPW Technology)

This presentation describes how powder rheometry is being applied to develop an increased understanding of how powders perform in AM ...

Using Powder Flow Measurements to Predict the Performance of Powder Feeders

Tim Freeman, Doug Millington-Smith, John Yin (Freeman Technology) and Daniel Buechi, Tobias Weber, Ralf Weinekotter (Gericke AG)

This study demonstrates how it is possible to generate a design and operating model based around the measurement of robust ...

The Development of a Multivariate Model for Predicting the Performance of Powder Feeders on a Comprehensive Range of Particulate Materials

Tim Freeman, Brian Armstrong, Doug Millington-Smith (Freeman Technology) and Daniel Buechi, Tobias Weber, Ralf Weinekotter (Gericke AG)

This study is designed to evaluate the potential of rapidly generating a simple and robust performance model for two types ...

Powder Rheology of Steel Powders for Additive Manufacturing

O. Lyckfeldt, Swerea IVF AB, Sweden

Powder rheology provides a novel tool for advanced evaluation of dry flow properties of metal powders. In this study, four ...

Quantifying the Effect of Caking by Powder Rheometry

Tim Freeman, Brian Armstrong, Katrina Brockbank, Freeman Technology

This poster presents some key results from three case studies which evaluate the flow properties of three different powder systems ...

Investigation of the Influence of Atomic Layer Deposition Coatings on Powder Rheology

Tim Freeman, Xiaowei Fu, John Yin, Freeman Technology and David M. King, Dean S. Dinar, PneumatiCoat Technologies

The current economic climate necessitates the reduction in the costs of industrial manufacturing processes while maintaining high productivity and product ...

Filling of Powders for Dry Powder Inhalation Using a Vacuum Drum Filler

1Eva M. Littringer, 1Eugen Schwarz, 2Martin Lober, 2Karlheinz Seyfang 1MEGGLE Excipients & Technology, 2HARRO HÖFLIGER Verpackungsmaschinen GmbH

This study investigates the influence of powder properties on the filling behavior of a vacuum drum filler for DPI application.

A Investigation into the Effects of Formulation, Vessel Scale and Method of Water Addition on Batch Granulation

Tim Freeman, Jamie Clayton, Mike Delancy, John Yin, Freeman Technology; and Filip Van der Gucht, ProCept Particle Processing Equipment

It has been demonstrated that there is a link between the quality of a wet mass/dry granulate (as measured by ...

Homogeneous and Non-Homogeneous Caking and Crusting in Powders

Tim Freeman1, Katrina Brockbank2, John Yin1, Mike Delancy1, 1Freeman Technology Inc, 2Freeman Technology Ltd

Materials are often stored for extended periods during processing and some will gain strength due to particle/particle interaction. This is ...

Powder Rheology as a Tool to Determine Optimum Blending Time

S. V. Kamath, A. Ekpe, P. Nayak, J. Meisel, E. First Bayer HealthCare, Consumer Care Division, Morristown, New Jersey

Powder Rheology can be utilized to characterize powder behavior and provide data on key properties such as compressibility, permeability, and ...

Utility of Powder Rheology in Selection of Flow Aid and Lubricant in Dry Granulations

S. V. Kamath, A. Ekpe, P. Nayak, J. Meisel, E. First Bayer HealthCare, Consumer Care Division, Morristown, New Jersey

Powder Rheology can be utilized to characterize powder behavior and provide data on key properties such as compressibility, permeability, and ...

Quantifying the Effect of Ambient Moisture on Powder Flow Properties

Tim Freeman, B Armstrong, K Brockbank, J Yin Freeman Technology, Tewkesbury

This study investigates the effect of exposing powders to increasing humidity and evaluating the changes to the powder’s dynamic flow, ...

The Impact of Loaded Drug Dose and the Surface Roughness of the Coarse Lactose Carrier to the Fluidisation Characteristics of Dry Powder Inhaler Formulations

Hanne Kinnunen^1, Jag Shur^1, Gerald Hebbink^2 and Robert Price^1 ^1Pharmaceutical Surface Science Research Group, Department of Pharmacy and Pharmacology, University of Bath, Bath, BA2 7AY, UK^2DFE Pharma, Borculo, Netherlands

This study shows how to develop a method for measuring the pressure drop across the powder bed during fluidisation experiments ...

Powder Rheology Analysis as Tool for the Characterisation of Interactive Powder Mixtures

E Cordts & H Steckel Department of Pharmaceutics and Biopharmaceutics, Christian Albrecht University Kiel Grasweg 9a, 24118 Kiel, Germany

In this study powder rheology analysis has been used to characterise interactive inhalation powder mixtures. With the diverse techniques provided ...

Powder Rheology as a Tool to Predict Impact of Different Sources of Excipient on Tablet Compression

F. Opawale, K. Landgren, L. Wagner, S. Suralik, P. Nayak, J. Miesel and E. First Bayer HealthCare, Consumer Care Division, Morristown, New Jersey

Powder rheology is utilized to characterize powder behavior and provide data on key properties such as compressibility, permeability, and basic ...

The Application of QbD to Pharmaceutical Powder Processing

Tim Freeman, Freeman Technology

In order to better understand the relationship between powder properties and in-process behaviour, modern instrumental methods – such as powder ...

Measuring Meaningful Powder Flow Properties – the Limitations of ‘Compressibility Index’ Data

Tim Freeman^1, Brian Armstrong^1 ^1Freeman Technology, Welland

The Compressibility Index (the relationship between a poured bulk density and tapped bulk density), developed by Carr, is still widely ...

To Develop and Evaluate New Methodology for Excipients Compatibility Together with API’s using Rheological and Thermal Tools

Maitri R. Trivedi, Rutesh H. Dave, Ph.D. Division of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy, Long Island University,Brooklyn, NY

Most of the Drug Dosage Forms are made from solid powder state (Tablets & Capsules) the flow of which can ...

Novel Applications of Traditional Lubricants Using a Dry Particle Coating Technique to Improve the Functionality of Cohesive Drug or Excipient Powders

Qi Tony Zhou^1, Li Qu^1, Ian Larson^1 , Brian Armstrong^2, Peter J Stewart^1, and David A V Morton^1 ^1Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Australia, ^2Freeman Technology, Worcestershire

Powder bulk functionalities such as flow, fluidization and aerosolization are fundamental to the handling and performance of many pharmaceutical ...

The Relationship Between Powder Flow Properties and Dosing Machine Geometry for Pharmaceutical Die Filling Applications

Xiaowei Fu^1, Tim Freeman^1, Graham Shirley^2, Brian Armstrong^1, Jeremy Baker^2 ^1Freeman Technology, Welland ^2Molins ITCM, Coventry

Filling machines have complex geometry through which powder has to flow and a significant requirement for filling processes when manufacturing ...

The Characterisation of the Physical Properties of Wet Masses

Jamie Clayton, Tim Freeman, Reg Freeman, Xiaowei Fu, Brian Armstrong Freeman Technology

For this work, a grade of lactose (food grade, Dairy Crest) and a microcrystalline cellulose (PH101, FMC) were used to ...

Characterisation of the Flow Properties of a Novel Spray Dried Tobramycin Powder For Dry Powder Inhalation (DPI)

Francesca Buttini, Brian Armstrong, Tim Freeman, Mark Saunders, Paolo Colombo Department of Pharmacy, University of Parma; Freeman Technology; Synectix Pharmaceutical Solutions

In this study, the FT4 Powder Rheometer was used to characterize a novel spray dried powder of tobramycin developed for ...

To Measure the Additive Effect of Magnesium Stearate and Stear-O-Wet on Wet Granulation

P. C. Okoye, S.H. Wu, R.Pugh, J. Yin, T. Freeman, R.H. Dave Long Island University; Covidien; C-THERM Technologies; Freeman Technology; Kolmar Labs Group

The purpose of this study was to determine the effects of magnesium stearate and stear-o-wet on wet granulation while adding ...

Flow and Compaction Characteristics of A Direct Compression Formulation (2)

Dong Yang, John Yin, Iqbal Bhuiyan, Narendra R. Desai, Syed M. Shah Pfizer Formulation Development; Freeman Technology

Direct compression is one of the major process technologies for tablet manufacture in industry. It shows advantages compared to other ...

Flow and Compaction Characteristics of A Direct Compression Formulation (1)

Dong Yang, Jennifer Q. Liang, Kevin Yoo, Iqbal Bhuiyan, Narendra R. Desai, Syed M. Shah Pfizer Pharmaceutical Development; Pfizer Product Development, Pfizer, Pearl River, NY 10965 (USA)

The flow properties of blends, a very important factor of tableting process, affects the characteristics of powder transfer and die ...

Determining Endpoint for Wet Granulation Using Rheological and Effusivity Measurement

H.H. Patel, S. Wu, R.Pugh, T. Freeman, B.Armstrong and R.H. Dave Long Island University; Covidien/Mallinckrodt; C-THERM Technologies; Freeman Technology

Though wet granulation is a common unit operation its accurate end-point determination still remains a challenge in pharmaceutical industry.The objective ...

The Effect of Fluid-Bed Granulation Process on the Physical and Mechanical Properties of Powders and Granules

Kevin H. Yoo, Zafar Ali, Chimanlall Goolcharran, Krishnendu Ghosh, Ruchi Shah, Jovita Tauro and Arwinder Nagi Pfizer Pharmaceutical Development Centre, Pfizer, Pearl River, NY 10965 (USA)

The objectives were to compare and characterize the physical and mechanical properties of powders and granules after the fluid-bed granulation ...

An Investigation into the Wall Friction Angle of a Range of Low Friction Materials Used in the Manufacture of Pharmaceutical Processing Equipment

Tim Freeman^1, Xiaowei Fu^1, Brian Armstrong^1 and Karlheinz Seyfang^2 ^1Freeman Technology, Welland ^2Harro Höfliger Verpackungsmaschinen GmbH

Using the FT4 Powder Rheometer this study evaluated a total of 15 coupons, with different wall material, surface roughness and ...

Characterisation and Functionality of Anhydrous Inhalation Lactose

C Pitchayajittipong^1, J Shur^1, J S Kaerger^2, S Edge^3 & R Price^1 ^1Pharmaceutical Surface Science Research Group, University of Bath, Bath, UK ^1Aeropharm GmbH, Rudolstadt, Germany ^1Novartis Pharma AG, Basel, Switzerland

The aim of this study was to characterise the physiochemical properties of several different grades of inhaltion lactose to further ...

Evaluation of Lubricants for Making Tablets Containing High-loading of Acetaminophen

Brian Cheng and Stephen Wu Covidien / Mallinckrodt Pharmaceuticals

The objective of this study was to evaluate five lubricants - Magnesium Stearate Monohydrate (MgST-M), Magnesium Stearate Dihydrate (MgST-D), Stear-O-Wet ...

Effects of Lubricants at Different Operating Speeds in the Tableting Process on Quality of Tablets Containing High-loading of Acetaminophen

Brian Cheng, Dan Ramlose, Gary Nichols and Stephen Wu Covidien / Mallinckrodt Pharmaceuticals, 385 Webster Groves, MO 63119

The objective was to evaluate the effects of magnesium stearate mono hydrate (MgSt-M) and magnesium stearate dihydrate (MgSt-D) at two ...

Evaluation of Stear-O-Wet as a Lubricant for Making Tablets

Stephen H. Wu, Brian Cheng, Dan Ramlose and Gary Nichols Covidien / Mallinckrodt Pharmaceuticals

The objective of this study was to determine the effects of Stear-O-Wet on powder flow, tableting process parameters, tablet wetting ...

Evaluating the Impact of Particle Size Reduction Techniques on the Powder Properties of Pharmaceutical Solids

Yang Guo, Neera Jain, Jimin Xiong, Ada Eluwa and Suresh Babu Synta Pharmaceuticals Corporation, Lexington, MA 02421

The objective of this study was to evaluate the impact of different particle size reduction techniques on the particle characteristics ...

Discrete Element Simulations of a Powder Rheometer: A Study of Particle Property Effects

Rahul Bharadwaj, William Ketterhagen and Bruno C Hancock Pfizer Global Research & Development, Groton Laboratories, Pfizer Inc, Groton, CT 06340

A numerical study of the Freeman Powder Rheometer using discrete element computer simulation (DEM). To understand the effect of particle ...

Development of a Material Sparing Method to Determine Powder Permeability to Air

Glenn Carlson, Bruno Hancock Pfizer Global Research & Development, Groton Laboratories, Pfizer Inc, Groton, CT 06340

A study to develop a material sparing method to detemine the air permeability of powders as a function of consolidation ...

A Critical Evaluation of Two Commercial Shear Cell Instruments for Determining the Flow Properties of Powders

Paul D. Jager and Frank M. Etzler Boehringer-Ingelheim Pharmaceuticals, Inc., Pharmaceutical R&D, 900 Ridgebury Road, P.O. Box 368, Ridgefield, CT 06877 (USA)

In this study, the performance of two commercial rotational shear cell instruments is compared with respect to cell geometry and ...