Evaluating powder characterisation techniques to optimise a dry granulation process

Thursday 6 October 2016

An experimental study was done to determine the correlations between the dynamic, shear and bulk properties of granules and the roller compaction process variables applied to make them.

Dry granulation by roller compaction is a routinely applied continuous process to convert fine, difficult to handle powders into uniform granular products that flow freely and perform efficiently in subsequent manufacturing steps.

The advantages of roller compaction include relatively modest capital investment, low running and maintenance costs, and high energy efficiency. Particularly suitable for moisture- or heat-sensitive materials and those that require ultra-high containment, dry granulation is an important step in the production of many pharmaceuticals, foods and chemicals, including detergents, plastics and toners.

Gerteis Maschinen + Processengineering (Jona, Switzerland) is a market leader in the design and supply of premium roller compaction equipment. In this article, results from a collaborative study between Gerteis and Freeman Technology are presented, to identify powder properties that characterise dry granulates in a commercially relevant way and support the optimisation of roller compaction processes. The study assessed the potential of dynamic, shear and bulk powder properties within this context.

For more visit Manufacturing Chemist Pharma.