Flow and Compaction Characteristics of A Direct Compression Formulation (2)
Direct compression is one of the major process technologies for tablet manufacture in industry. It shows advantages compared to other processes including labor and cost saving, fewer manufacturing steps, and greater suitability for moisture sensitive API, etc. In this process, the flow properties and compaction properties of dry blends affect the final quality of compressed tablets, such as hardness and weight variation, etc. So, the characterization of these properties are critical in tableting process development. In this study, a 3x2 DOE was used to study the effect of excipients on the compaction properties (Yield Pressure) and flow properties of the blends. Presented at AAPS 2009.