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17
Sep
2019
The influence of roller compactor process parameters on granule properties

The influence of roller compactor process parameters on granule properties

Freeman Technology is pleased to announce the release of a new application note that demonstrates the value of powder rheology as a tool for reliably detecting and quantifying the effect of changing roller compactor process settings.

Processing powder blends can present a number of challenges: component powders may be poorly flowing in the process, the blends may be susceptible to segregation, or the formation of agglomerates may affect homogeneity. Granulation is used in a range of industries and applications to combine multiple components of a blend into a more free-flowing, homogeneous intermediate product for downstream processing. It is frequently carried out as a wet process, but the resultant wet mass has to be dried and milled to generate a processable product. This can be time consuming and expensive, and in some cases not possible due to chemical and/or thermal degradation of the active ingredient.

Dry granulation has significant benefits in terms of both processing and cost reduction, and can be used with sensitive materials. However, there is little indication of which process parameters produce optimal granulate quality in order to achieve interruption free processing and high quality products. Most equipment suppliers and product manufacturers therefore rely on historical and ad-hoc trial information to identify suitable parameters.

This application note details the joint study undertaken by Freeman Technology Ltd. and Gerteis Maschinen+Processengineering AG, to investigate how process parameters influenced the properties of the dry granulate of a placebo formulation.

The application note is available in English, Chinese, German and Japanese. Please scroll to to the bottom of the page to download.

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